英国爱丁堡大学博士后 生物学

英国博后信息 物理、天文、生物信息、材料
截止日期： 2009年2月27日
方向：物理、天文、生物信息、材料
学校：爱丁堡大学
爱丁堡大学介绍： http://www.docin.com/p-7285825.html
申请地址：
http://www.jobs.ed.ac.uk/vacancies/index.cfm?fuseaction=vacancies.detail&vacancy_ref=3010356
详细信息请点击标题：
INFORMATION for CANDIDATES

This document is designed to give you as much information as possible about the role you have applied for.

Job description:
Funding body: SULSA (Swain) / Wellcome Trust (Tyers)Hours: Full-time (35hrs/week) Start date: ImmediateDuration: fixed term 12 months (with possibility of renewal) Supervisor: Profs. Peter Swain and Mike TyersInformal enquiries: Peter.Swain@ed.ac.uk

Background:
We study the systems biology of cellular decision-making and are interested in how genes and proteins interact to allow cells to sense, process, and respond to altering environmental conditions. In particular, we are focusing on how fluctuations in nutrient levels impact new gene expression and the cell cycle in budding yeast.

The responses of individual cells can be qualitatively different from the average response of a population. We are developing microfluidic devices both to enable tracking of the size of cells and their levels of gene expression over time and to allow rapid, but controlled, changes in extracellular conditions. At the same time, we are writing image processing and analysis software to automate data acquisition and will build our results into mathematical models. It is therefore essential that you have an interest and enthusiasm for multi-disciplinary research.
We anticipate the position having a substantial degree of independence. You will be responsible for the molecular biology of the project, including designing and constructing fluorescence-based reporters, and will help construct the microfluidic devices and develop protocols for time-lapse microscopy. You will contribute to the design of the experiments and interact frequently with modellers. There will be ample opportunity for you to improve your skills in microscopy and image and data analysis.

You will be based in the Centre for Systems Biology (CSBE) at Edinburgh in the new Waddington building (opening Spring 2009) on the Kings Buildings campus of the University of Edinburgh. CSBE is one of the six centres for Systems Biology established by the U.K. government and currently consists of eleven research groups. It offers an excellent environment for people wishing to transition into Systems Biology with a mixture of dry and web labs and offices and laboratory space side-by-side. You will also be part of the focus of the Scottish Universities Life Sciences Alliance focus on Systems Biology, a collaboration between six of the research universities in Scotland and the Scottish government.

Job Profile:
1. To take responsibility for the planning and execution of biochemical, molecular genetic, and microscopy aspects of the project.
2. Contribute to the overall project development, interacting with both theoretical and experimental researchers.
3. Contribute to the publication of research findings, drafting of papers for publication, presentation at conferences.
4. Provide advice and assistance for junior staff and research students as required.
5. Develop new methods and techniques appropriate to the goals of the project.

Person specification:
Essential
1. A PhD in biochemistry, molecular genetics or a related area.
2. Research experience and international-quality publications in molecular genetics of budding yeast.
3. Experience with several of the following: molecular genetics of budding yeast, reporter gene methods, in vivo imaging and fluorescence microscopy, microfluidics, micro-manager.
4. Enthusiasm for combining computational and experimental work.
5. Proven ability in team working, preferably cross-disciplinary teamwork.
6. Excellent English communication and writing skills.

Desirable
1. Some programming abilities.
2. Experience in image processing .

Salary
The role is grade UE07 and attracts an annual salary of £29,704 to £35,469 for full-time hours. Salary is paid monthly by direct transfer to your Bank or Building Society account, normally on the 28th of each month. Salaries for part-time staff are calculated on the full-time scales, pro-rata to the Standard Working Week.
We anticipate interviews will be held in the week commencing 23rd February. If you have not been invited for interview by this date, you have not been successful.
GENERAL INFORMATION The University of EdinburghFor information about the University of Edinburgh, please visit http://www.ed.ac.uk/about/ The College of Science and EngineeringFor information about the College of Science and Engineering, please visit http://www.scieng.ed.ac.uk/About/index.asp The School of Biological Sciences The School of Biological Sciences is located at the King's Buildings campus. It includes about 125 academic staff and independently-funded senior research fellows, around 200 research assistants, most of whom are postdoctoral, 150 technicians, 50 administrative and IT staff and approximately 200 postgraduate research students. Research grant expenditure is currently about £20M per year. The School comprises six research-focused Institutes with a strong inter-disciplinary remit: Structural and Molecular Biology, Cell Biology, including the Wellcome Trust Centre for Cell Biology, Stem Cell Research, Immunology and Infection Research, Evolutionary Biology, and Molecular Plant Science. Research of the highest international standard is conducted over a wide range of pure and applied biological science Postgraduate research students are members of the Graduate School of Biological Sciences, and the School is a partner in the Wellcome Trust 4-year PhD Programme. The School's teaching programme includes both undergraduate and taught Masters degrees, with some 1600 students enrolled on our degree programmes. Many programmes are taught jointly with other Schools, in particular with Biomedical Sciences and GeoSciences. About 400 students are admitted each year to read biological subjects, across 15 Honours Schools and 4 MSc programmes. The administration of teaching is co-ordinated by the Biology Teaching Organisation. For more information please visit the BTO web-site at http://www.bto.ed.ac.uk/ Further information about the School of Biological Sciences and its constituent Institutes is available on the Web at http://www.biology.ed.ac.uk/
Centre for Systems Biology at Edinburgh ( http://www.csbe.ed.ac.uk/ )The Centre for Systems Biology at Edinburgh (CSBE) brings together two of Edinburgh University's great strengths, world-class informatics and world-class biology, as part of the University's vision "to integrate the physical with the life sciences". CSBE is one of six UK 'Centres for Integrative Systems Biology' and the only one in Scotland. It is initially supported by an £18M investment from BBSRC, EPSRC, and the University of Edinburgh. CSBE aims to integrate biological data and mathematical models into large-scale informatics infrastructure and apply novel tools to understand a range of dynamic biological processes. It draws expertise from eleven internationally-leading Systems Biology research groups in the Schools of Biological Sciences, Informatics, Engineering, and BioMedical Sciences, together with staff at the Mathematics Department of Heriot-Watt University and at Biomathematics and Statistics Scotland. The biological pilot projects include RNA metabolism in yeast (Jean Beggs, David Tollervey), interferon signalling in human macrophages (Peter Ghazal), and the plant circadian clock (Andrew Millar). The Kinetic Parameter Facility provides core experimental support for molecular biology, biochemistry and biophysics, including robotised q-RT-PCR, automated ITC, SPR and high-resolution MS, with additional expertise in micro-fabrication and micro-fluidics (Anthony Walton).Strong interdisciplinary links with other Schools and Research Centres are a key part of CSBE's research. CSBE is collaborating on protein characterisation with the Centre for Translational and Chemical Biology (CTCB) and will benefit from CTCB's outstanding facilities for protein production. The computing facilities for CSBE are integrated with those of the Edinburgh Centre for Bioinformatics (ECB). The Division of Pathway Medicine's excellent microarray facility is available to CSBE, including novel developments in micro- and nano-scale assays jointly with the Scottish Microelectronics Centre (SMC). Very strong computational support is available from the Edinburgh Parallel Computing Centre, which runs the UK's national supercomputers, and from the UK National E-Science Centre, which is based jointly in Edinburgh and hosted by the University. This positions CSBE to create a seamless research continuum in interdisciplinary biology.Life Sciences in the City of EdinburghEdinburgh and its surroundings provide one of the largest groupings of bioscience researchers in the UK. Local research partners include Heriot-Watt University, the SEERAD-funded Biomathematics and Statistics Scotland (located on the Kings Buildings campus), and the BBSRC Roslin Institute. Links to knowledge transfer organisations are strong with a bioscience incubator on campus and the Edinburgh Science Park based just outside the city, including the Edinburgh Technopole.As a place to live the City of Edinburgh has all the advantages of a European capital city with a distinctive historical and architectural heritage and a vibrant cultural life including the world's largest arts festival. It is also within easy access of some of the most beautiful country and highland scenery to be found anywhere.

Application Procedure:We encourage all applicants to apply online at http://www.jobs.ed.ac.uk/ . The application process is quick and easy to follow, and you will receive email confirmation of safe receipt of your application. The online system allows you to submit a CV.If you do not have access to a computer, you can call our recruitment line on 0131 650 2511 for an application pack. This will be posted out to you for you to complete and return. Please return the Application form and all enclosures (except the equal opportunities form) to SBS Contracts, School of Biological Sciences, School Office, Darwin Building, The Kings Buildings, Edinburgh, EH9 3JR by the closing date of 27 February 2009. Return the equal opportunities form in the separate prepaid envelope.To complete the application process both online and in paper format, you need to complete the (i) Application Form (ii) Additional Personal Information Form, (iii) Equality & Diversity Monitoring Form, and (iv) Rehabilitation of Offenders Form and (v) full curriculum vitae and (vi) the names and contact details (including email) of two referees. You should additionally include a letter of application outlining how you meet the person specification and what you would bring to the post. We cannot guarantee to consider late applications. Please quote reference no: 3010356

Closing date: 27 February 2009

The University reserves the right to vary the candidate information or make no appointment at all. Neither in part, nor in whole does this information form part of any contract between the University and any individual